Lake Tahoe is about a 2 hour drive from Sacramento Airport that passes through beautiful scenery of the Sierra Nevada Mountains and El Dorado County Wine Country.  There are numerous wineries around Placerville, CA.  Lake Tahoe is about 1.5 hr from Reno Airport.  Also beautiful scenery along the way.  Both routes offer ample detours for walking/hiking/exploring.  Airport transportation is available via the South Tahoe Express shuttle from the Reno Airport.  http://www.southtahoeexpress.com/ or call 1-775-325-8944 or toll free at 1-866-89-TAHOE ($29.75 per person one way, $53.00 per person round trip).